tumour suppressor

tumour suppressor
(= antioncogene; cancer susceptibility gene)
A gene that encodes a product that normally negatively regulates the cell cycle, and that must be mutated or otherwise inactivated before a cell can proceed to rapid division. Examples: p53, RB (retinoblastoma), WT-1 (Wilms&’ tumour), DCC (deleted in colonic carcinoma), NF-1 (neurofibrosarcoma) and APC (adenomatous polyposis coli).

Dictionary of molecular biology. 2004.

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